These results demonstrate new, previously ...

Use

pneumococcal capsular polysaharydnoy (DCA) based vaccine resulted in a significant reduction in invasive pneumococcal disease

. However, still much to learn about the vaccine immunity and semyvalentnom PPS-linked protein vaccines

use in children was associated with the replacement of nonvaccine serotypes and 23-valent vaccine used in adults did not prevent pneumococcal pneumonia

. This report shows that a PPP-specific monoclonal antibodies (mat) >> << increase conversion rate of two different

Streptococcus pneumonia serotypes. This phenomenon was mediated PPS-specific monoclonal antibodies that stick together, but do not contribute opsonicheskoy effector cell killing

homologous serotype in vitro. Compared with autoinduktoriv, ​​competence stimulating peptide (CSP) only transcription profiles of gene expression pneumococcal >> << after incubation with UPC and one of the MAb to PPS of serotype 3 The change in terms of competence

(

com) and related bacteriocins-like peptide (BLP) of genes involved in pneumococcal quorum. This MAb was also found to cause almost 2-fold increase CSP2-mediated

bacterial killing or fratricide. These observations suggest novel, direct effect of PPS-binding mat of pneumococcal >> << biology, which is essential for antibody immunity to pneumococcus in the era of pneumococcal vaccine. Taken together, our data suggest >> << first unexpected mechanism by which PPS-specific antibodies may affect the genetic exchange and bacterial viability >> << In the absence of cells of the host. The current of thought believes that the pneumococcal polysaccharide capsular (PPS)-binding antibodies protect against pneumococcus on

causing effector cells killing opsonicheskoy homologous serotype. Although these antibodies play an important role as pneumococcal vaccines

Protection against pneumococcal infection, PPS-specific antibodies that do not show activity, but is very protective against pneumococcal

infection in mice were found. In this article the influence nonopsonic PPS-specific monoclonal antibody

(mat) with biology

pneumococcus. The results showed that the presence of competence stimulating peptide (CSP), such mat increase the frequency of pneumococcal transformation >>. << Further investigation of one such MAb showed that he changed the expression of genes involved in quorum

and increase competence caused by killing or fratricide. These results suggest new and previously unexpected mechanism >> << a certain PPS-specific antibodies directly affect pneumococcal biology that has broad implications for bacterial >> << design, genetic exchange and antibody immunity strattera 40mg to pneumococcus. .